John, I am a Windows PC user so have no experience and knowledge of Mac and its OS.
That said, I make 1-take videos using OBS. It allows me to use either a USB webcam or my phone for the video and record audio from a variety of sources. Those audio sources include my Interface using its ASIO drivers as well as a feed from my DAW. I am also able to use some of the fx-plugins I use in my DAW in OBS, so no longer include my DAW in the recording setup for a 1-take.
I am pretty sure you could do it that way. But maybe worth taking a look at OBS (it has a download option for MacOS) and exploring possible ways to route audio on a Mac to use OBS for a 1-take.