I’ve experimented with stereo amp setups. I think it sounds pretty cool, but it can be tough to translate that impact into a band or full song mix. Depends on the song, instrumentation, et cetera.
When using two amps I’ve had better luck with the wet/dry approach (e.g. a dry Marshall and a wet Fender together). Wet/dry/wet is pretty cool, too, because you get the whole wet/dry thing, but your wet part can take advantage of stereo delays and reverb and such, which is where the stereo thing seems to shine the most, anyway.
I’ve used wet/dry with amp sims, as well as with real amps. If I recall correctly, this recording used two amp sims in the Boss GT-1000 Core) set up in a wet/dry configuration. I believe I added a stereo reverb in the DAW, too.