Very strange. I never had any issues with my focusrite on Win 11. I use Ableton instead of Reaper, and use a modeller rather than software amp, so that might have something to do with it. Even ran a super low buffer size to get latency as low as possible. My Windows PC is very powerful though, loads of CPU cores - so maybe that has something to do with it. I’m now on Mac though, which is also fine with the Focusrite. I bet it’s a PC thing rather than the Focusrite hardware TBH.
A couple of years back, well before the TMP, I was tossing up whether to go the software or amp route. I ended up with the Fender GTX50 amp for cheaper than the software stack I was looking at (Amplitube + midi footswitch). The TMP is totally awesome btw, sounds so good 
I’ve heard Neural DSP is also awesome but I’ve never used it.