Surya,
I use Waves GTR when I want to record guitar parts on for original songs in my DAW. I know it runs standalone but haven’t tried that.
I guess the first challenge would be to have a PC setup so the latency in the round trip from guitar-AI-app-AI-speakers/headphones is short enough to make it. workable. Lots written about this here: Is there a way I can record, hear myself, and not have latency with an audio interface?
Then I suppose it would be the quality of tones. I’ve not tried lots of these software applications but I believe they generally produce good quality.
As another option I understand you get pedals that can serve a similar purpose with option to listen on headphones or an external speaker. Depending on your use cases, that may be a better option?